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Faculty: Dr Richard Miron, Dr. Mark Bishara

April 26,27 Toronto,ON


Friday - 8:00am - 5:00pm
Saturday - 8:00am - 5:00pm

CE Credits:
16 Credit Hours (AGD PACE Approved Provider)


Miele Experience Centre Toronto

161 Four Valley Dr, Concord, ON L4K 4V8

Next Generation Biomaterials for Bone and Periodontal Regeneration


New and innovative biomaterials are being discovered or created in laboratories at an unprecedented rate, but many of them remain entirely foreign to practicing clinicians. This course addresses this gap in knowledge by summarizing some of the groundbreaking research performed to date on this topic and providing case examples of these biomaterials at work. The course begins with a review of the biologic background and applications of bone grafting materials utilized in dentistry. The principles of guided tissue and bone regeneration are covered in detail, including many recent advancements in barrier membrane technologies as well as use of platelet-rich fibrin and various growth factors, and many next-generation materials that will optimize future bone and periodontal regeneration are presented. The final section of the course is designed to help clinicians select appropriate biomaterials for each specific regenerative protocol. Much like one implant size and shape cannot be utilized for every indication in implant dentistry, one bone grafting material, barrier membrane, or growth factor cannot maximize regenerative outcomes in all clinical situations. This course teaches clinicians how to utilize biomaterials in an appropriate, predictable, and evidence-based manner.


Day 1 Objectives: Understand the different available options for bone grafts and their uses. Understand when to utilize each class of bone grafting material appropriately


8:30-9:30: Biomaterials and their effect on immune health and tissue integration. How to optimize regenerative strategies by minimizing immune responses. How to supplement patients with antioxidants, vitamin D and other vitamins to minimize graft/implant failure.


9:30-10:15: Classification of bone grafting materials. Current uses and percentages of bone grafting materials in North America. Why do we use autografts versus allografts, versus xenografts versus synthetic materials.


10:15-10:45: Coffee break


10:45-11:15: Autogenous bone, the gold standard of bone regeneration. Importance of harvesting techniques. When block graft, when particles. The bone scraper and its simplistic use in implantology. Introduction to the concept of bone conditioned media (BCM).


11:15-12:00: Allografts, the standard replacement material. Differences between freeze-dried bone allograft (FDBA) and demineralized freeze-dried bone allografts (DFDBA). Clinical uses of FDBA versus DFDBA. When to use DFDBA versus FDBA? Understanding that processing technique of bone allografts is extremely important for bone-inducing potential and that not all allografts are the same.


12:00-1:00: Lunch break


1:00-1:45: Xenografts – why are they so heavily utilized in North America? What are their advantages and disadvantages. Clinical cases presented with their relative indications.


1:45-2:30: Synthetic materials – uses and limitations. Osopia, the next generation and first osteoinductive synthetic bone graft.


2:30-3:00: Break


3:00-3:45: Dentin Grinder – uses and limitations. Does every tooth deserve a second chance at bone grafting?


3:45-4:00: Live demo of the dentin grinder


4:00-4:45: Tetranite, a novel bone adhesive that adheres dental implants directly to bone giving optimal primary stability of dental implants. Discussion on the future of 3D printed bone grafts


Day 2 Morning Objectives: Understand the objective use of barrier membranes and platelet rich fibrin.

8:30-9:30: Barrier membranes, when non-cross-linked, when cross-linked? When non-resorbable? When titanium? Expert discussion with case presentations from the leaders in the field.

9:30-11:00: Advanced concepts in platelet rich fibrin (PRF). What you don’t know about PRF that you probably should know. Updates from the Miron Research Lab.

11:00-12:00: Blood draws with advanced concepts. Novel centrifugation speeds and the future of PRF tubes.

12:00-1:00: Lunch

Day 2 Afternoon objectives: Understand why growth factors are the future of bone and periodontal regeneration. Understand each class of growth factors and their uses.

1:00-1:30: Growth factors for bone regeneration. BMP2 and BMP9. Uses and applications. When to replace autogenous bone harvesting?

1:30-2:15: Enamel matrix derivative (Emdogain) and its effect on periodontal regeneration. Osteogain, a next generation growth factor for periodontal regeneration.

2:15-2:30: Combination approaches to periodontal regeneration. Clinical uses of rhPDGF (Gem21) and rhFGF2

2:30-3:00: Break

3:00-3:30: Use of Hyaluronic Acid for soft tissue regeneration. Is it a next generation biomaterial? Clinical evidence from European studies.

3:30-3:45: Ion incorporation into bone grafts for bone and periodontal regeneration. Can we 'dope' bone grafts? Use of gene therapy for growth factor delivery – is there a future?

3:45-5:00: Clinical recommendations and guidelines for selecting appropriate biomaterials for bone and periodontal regeneration in an appropriate, predictable, and evidence-based manner. Evidence discussing what biomaterials to use for extraction sockets, sinus augmentations, GBR procedures, around implants, periodontal regeneration, and recession coverage.


Dr. Mark Bishara completed his undergraduate studies in medical biophysics, at the University of Western Ontario and was a gold medal recipient as top graduate of his program. He went on to complete his Doctor of Dental Surgery degree at the Schulich School of Medicine and Dentistry. Since graduating, he practices in the Durham region with a focus on digital workflow, dental implants, bone grafting material regeneration and tissue regeneration. He currently collaborates with members of the Miron Lab in the United States on tissue regeneration utilizing Platelet Rich Fibrin(PRF). He is a published author on PRF , immediate dental implants and clinical applications. He is the President and founder of the Canadian Implant Dentistry Network, Canada’s largest online implant community. He is on the advisory board of Spectrum Implants, the only peer reviewed implant journal in Canada as the Implants Product Review Editor.

Dr. Mark Bishara is an active lecturer with the Toronto Implant Academy on dental implants and is a  published author on topics such as PRF treatment and dental implants.

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Dr. Richard Miron is currently an Adjunct Visiting Faculty in the department of Periodontology in Bern, Switzerland where he completed his PhD studies since 2009. He has currently published over 150 peer-reviewed articles and lectures internationally on many topics relating to growth factors, bone biomaterials and guided bone regeneration. He has recently been awarded many recent international prizes in dentistry and is widely considered as one of the top contributors to implant dentistry having won the ITI Andre Schroeder Prize, the IADR Young Investigator of the Year in the field of Implant Dentistry, and the American Academy of Implant Dentistry Young Investigator grant award. He has written 2 textbooks widely distributed in regenerative dentistry including his most recent titled: “Next Generation Biomaterials for Bone and Periodontal Regeneration” and a 2nd in 2017 titled: “Platelet Rich Fibrin in Regenerative Dentistry: From Biological Background to Clinical Indications”.

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